The Global Down Syndrome Foundation (GLOBAL) is an American non-profit organisation founded in 2008, based in Denver, Colorado. It is distinguished by its direct connection to the Linda Crnic Institute for Down Syndrome at the University of Colorado — the first comprehensive academic centre for Down syndrome research in the United States. Website: globaldownsyndrome.org
What Healthcare Professionals Can Benefit From
GLOBAL is the most comprehensive medical reference for adults with Down syndrome:
- Medical Care Guidelines for Adults: the first evidence-based medical guidelines for the care of adults with Down syndrome, published in JAMA in 2020. They cover: mental and behavioural health, dementia and Alzheimer's disease, diabetes, heart conditions, osteoporosis, thyroid disorders, and coeliac disease. Available in English, Spanish, Italian, Albanian, Swahili, and Japanese
- Partnership with the Crnic Institute: access to advanced research findings on the Human Trisome Project studying molecular patterns, Alzheimer's research, congenital heart conditions, and Down Syndrome Regression Disorder (DSRD)
- International Organisation and Clinic Directory: a comprehensive database to help professionals locate specialist centres worldwide
What Researchers Can Benefit From
- Research Grants: GLOBAL has invested more than $6.7 million in research grants for 33 researchers to date, making it one of the largest research funders in this field
- The Human Trisome Project: the largest comprehensive biological study of people with Down syndrome, aimed at understanding the molecular mechanisms that affect health and development
- Research Collaboration Network: connections with researchers from universities and academies worldwide working on Down syndrome
What Families and Individuals Can Benefit From
- "Down Syndrome World" Magazine: an award-winning magazine publishing research, educational content, and inspiring stories from the Down syndrome community around the world
- Prenatal and Newborn Diagnosis Resources: comprehensive and balanced information for parents receiving a diagnosis, covering available options and support
- Angel Walk and Be Beautiful Be Yourself Events: annual fundraising events that also create a supportive community and social network for families
What Local Organisations Can Benefit From
- GLOBAL Education Awards Grants: the Foundation has awarded nearly $1.3 million to support 14 local and global programmes in 2025, backing educational and community programmes serving individuals with Down syndrome